CINCINNATI — Hunter Pence homered for the second straight game, and Cliff Lee got his sixth straight win Wednesday night, leading the Philadelphia Phillies to a 3-0 victory over the Cincinnati Reds that took them to a new high point.

The NL East leaders are a season-best 40 games over .500, boasting the majors' best record at 86-46.

Lee (15-7) extended the Phillie starters' domination, coming within one out of his sixth shutout. He left with two outs and the bases loaded in the ninth. Ryan Madson retired Yonder Alonso on a foul pop for his 25th save in 27 chances.

Pence homered off left-hander Dontrelle Willis (0-4), the Reds' hard-luck starter.

Cincinnati entered the series on a hot streak, winning four straight. The Reds ran into an old problem — they can't do anything against the Phillies' pitching.

The Phillies swept them in the playoffs last season, with Roy Halladay throwing a no-hitter. Philadelphia is 20-6 against Cincinnati lately, including 6-1 this season.

Philadelphia scored in the first inning when the Reds failed to turn a double play with two runners aboard. Pence led off the sixth with his 18th homer, extending his hitting streak to seven games. Philadelphia scored another run on a forceout in the seventh.

Lee, who celebrated his 33rd birthday on Tuesday, hasn't lost since July 25. The left-hander has given up only six earned runs in his last six starts. He's been especially tough on the road, where he hasn't allowed a run in his last 302⁄3 innings since July 19.

Lee retired the first two batters in the ninth, then gave up a double to Joey Votto, walked Jay Bruce and hit Miguel Cairo with his 117th pitch, forcing Manager Charlie Manuel to go to the bullpen.

No matter how well he pitches or hits, Willis can't get a win. He gets the lowest run support among Reds starters, and the bullpen has blown save chances in three of his starts. He gave up five hits in 62⁄3 innings.