'Plaques' can plague your heart

Deposits of cholesterol threaten health

Special to the Herald-LeaderNovember 20, 2011 

Dr. Thomas Whayne

UK HEALTHCARE

Heart disease, especially hardening of the coronary arteries, is a major medical problem in the United States and in Kentucky.

This hardening is actually a disease known as atherosclerosis, which involves abnormal deposits of cholesterol, called plaques. Without proper blood flow to the heart, survival is not possible. These plaques build up and can restrict blood flow so that chest pain, known as angina, can develop when obstruction is greater than 70 percent.

Heart attacks usually occur with obstructions of 40 percent to 50 percent. These plaques do not significantly obstruct the flow of blood in a coronary artery unless an emergency event occurs — usually a rupture of the plaque followed by the rapid clotting of blood over the rupture site.

While this clotting is a normal response by the body to repair the damage, the clotting proves to be even more harmful than the plaque itself. Severe damage to the heart muscle can result, depending on the size of the artery involved and amount of heart muscle affected.

If the patient survives, as occurs in most cases with quick emergency care, heart disability can still occur depending on the amount of muscle damage. The phrase "time is muscle" emphasizes why chest pain must be explained and, if a heart attack is suspected, emergency care must be given rapidly.

The standard of care is urgent cardiac catheterization. If accomplished quickly enough, it can save heart muscle. The obstructed artery is opened by balloon angioplasty, combined with stent placement. However, even if such emergency care is not immediately available, medical help should be sought as quickly as possible because other clot-busting and stabilization treatments might make a difference.

An even more desirable scenario involves educating patients on how to avoid heart attacks in the first place. Many of them can be avoided by lowering cholesterol, especially the "bad guys" known as low density lipoproteins, or LDL.

A healthy lifestyle is always a good idea, but frequently that is not enough. The statin class of medications is the major means of lowering the LDL. Like any treatment, statins can cause some problems, but the benefit far outweighs any risk. In addition to their potent reduction of LDL, they have several other effects that reduce cardiovascular risk.

The next frontier in prevention appears to be elevation of the high density lipoproteins, or HDL.

The good news is: future cardiovascular medicine offers the promise of more and more improvement in quality and prolongation of life.

Dr. Thomas F. Whayne Jr. is a professor of medicine at the University of Kentucky College of Medicine and a physician at the UK Gill Heart Institute.

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