After getting challenged by SMU early, Louisville got its offense going late in the first half and cruised to a win in the opener of American Athletic Conference play.
Shoni Schimmel scored 18 points, Sara Hammond had 14 points and 10 rebounds for her third double-double of the season, and the seventh-ranked Cardinals (13-1, 1-0) went on to a 71-51 win for their sixth straight victory.
Schimmel made 4 of the team's five three-point shots, and Bria Smith added 13 points and 11 rebounds.
Hammond said facing teams such as LSU, Oklahoma and Florida State has helped the Cardinals prepare for their AAC challenges.
"I think we've made strides throughout the season, especially with our non-conference, how hard of a schedule it was," said the junior forward. "To come out 12-1, that gives us confidence going into our conference."
Eastern Kentucky 90, IPFW 68: Marcus Lewis scored 17 points to lead Eastern Kentucky over Indiana-Purdue Fort Wayne. Eastern Kentucky (9-4) got 16 points and nine rebounds from Eric Stutz and 11 points from Corey Walden. Glenn Cosey added 10 points and five assists for the Colonels. IPFW (10-5) was led by Mo Evans with 13 points. The Colonels hit on 11 of 21 from beyond the arc and 59 percent overall from the floor. EKU is now 42-6 under Jeff Neubauer when scoring 80 or more.
Georgetown 113, Miami Hamilton 83: Three Tigers tallied double-doubles as Georgetown (10-2) routed Miami Hamilton at home. Monty Wilson led with 35 points and 14 rebounds. Deondre McWhorter added 24 points and 12 rebounds, while Trenity Burdine had 17 points and a game-high 16 rebounds. Russ Middleton and Bopper Stenzel also reached double figures with 10 points.
Dayton 72, Murray St. 51: Dyshawn Pierre had 19 points and 10 rebounds to lead host Dayton (10-3) over Murray State. Cameron Payne scored 13 points and had six assists to lead Murray State. Sapp added 12 points and had three steals.
No. 13 Florida 76, Savannah St. 34: Pat Young scored 15 points, becoming the 50th player in school history to reach 1,000 in his career as No. 13 Florida handled Savannah State. Young was one of four Florida players in double figures.