The Mount Vernon Police Department uncovered a meth lab being operated by two men in a room at the Days Inn near Renfro Valley early Tuesday.
A hotel employee contacted police just after 1 a.m. because of a "strong smell" coming from the room, said Assistant Chief William H. Barrett.
When police arrived, they found Robert D. Brumett, 44, and William K. Bullens Jr., 51, with two meth operations inside the room.
Brumett was charged with manufacturing methamphetamine, possession of marijuana, cultivation of marijuana and possession of drug paraphernalia.
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Bullens was charged with manufacturing methamphetamine, possession of marijuana and possession of drug paraphernalia.
Both were taken to the Rockcastle County Detention Center.