A two-alarm fire caused significant damage to Thoroughbred Printing at 904 North Broadway early Saturday.
About 50 firefighters worked much of the night to put out the fire, said Major Michael Bossert of the Lexington Division of Fire.
The printing plant sustained "significant" damage, but the office area of the large facility was not damaged, he said.
One firefighter was taken to the hospital after being temporarily pinned beneath debris that fell on his leg when the roof partially collapsed. Bossert said the firefighter was treated and released with no significant injuries.
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The cause of the fire was still unknown late Saturday afternoon; Bossert said the area where the fire started was unsafe for investigators to enter, and machinery would have to be brought in to make it safe.
Firefighters were called to the scene at about 12:30 a.m. after a neighbor discovered the fire. Smoke and flames were visible when firefighters arrived, Bossert said.
The fire-fighting work concluded at about 5 a.m., and investigators spent much of Saturday at the scene. Firefighters were still there late Saturday afternoon to make sure no new fires sprung up.
Thoroughbred Printing started as the Thoroughbred Press in 1946. Forty years later, it was sold to Host Communications. In 2007, a Northern Kentucky group bought the operation, and it became Thoroughbred Printing.
Barry Henry, a co-owner and chief financial officer for the company, said Thoroughbred is a commercial printing company that prints Keeneland's programs and does work for a number of other major clients, such as the University of Kentucky and Alltech.
It is part of a group of printing companies with locations in Dayton, Ky. and Middletown, Ohio. Those facilities will pick up the slack while the Lexington operation recovers, Henry said.
"Our customers should see no effect of this," he said, noting that only one customer order sustained damage, and most of that order had already been delivered.
Thoroughbred Printing has 20 to 25 employees, he said.