At least five people were injured in seven shootings between Friday night and Monday afternoon.
The most recent shooting occurred just after 4 p.m. Monday, when a woman sitting on a porch was hit by a stray bullet as two vehicles exchanged gunfire while driving at Fifth and Ohio streets.
"She was an innocent bystander," Lexington police spokeswoman Sherelle Roberts said.
The woman was taken to the hospital with a gunshot wound to the lower leg. Her condition was not immediately available.
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Roberts said one of the two vehicles was found shot up at Michigan Street and Charles Avenue soon after the shooting. Police were looking for the other vehicle, a dark SUV, she said.
Several people were inside each of those vehicles, and Roberts said "it's very likely" one of them might also have been shot.
Police Lt. Jesse Harris said a 17-year-old boy with an injury thought to be related to the shooting showed up at Good Samaritan Hospital Monday afternoon.
"We're still trying to determine what his role was," Harris said.
He said the teen's injuries were not thought to be life-threatening.
The recent rash of violence was the most since a four-week period in June and July, when four people were killed and at least a dozen were injured by gunfire.
Roberts listed six reports of shots being fired in Lexington since Friday night, not counting Sunday night's shots-fired alert on the University of Kentucky campus. UK officials said Monday they now think those shots were fired from an "airsoft pistol" or pellet gun, not a regular firearm. No arrests have been made in any of the shootings.
While no one sustained a life-threatening injury during any of this weekend's shootings, Roberts said police need the public's help to solve the cases.
Besides the shooting Monday afternoon, in which there were many witnesses who were cooperating with police, Roberts said information in the cases was scarce.
Roberts said some victims have been reluctant to talk with police, and that's why the public's help is needed.
"Because we haven't had the best cooperation from nearly all of the victims ... it's hard to really conclude whether these were targeted situations or what exactly led up them," she said. "We're having a hard time getting people to be really forthcoming with information."
Roberts stressed that people can give information to police without disclosing their names.
Two shootings that occurred Friday night might be connected, but the others appear unrelated, Roberts said. She said it was too soon to tell whether Monday's shooting was related to the others.
She said police have only "loose" suspects descriptions from some of the incidents but "nothing in the way of actually having people named."
"That's where we hope the public can help," she said. "It's tough when victims are not cooperative with us. We need the public to fill in those blanks."