Republican Thomas Massie, the Tea Party-backed candidate, handily defeated Democrat Bill Adkins in the race for Congress from Northern Kentucky's 4th Congressional District.
The seat was previously held by Geoff Davis, who retired.
Massie, the former Lewis County judge-executive, beat Adkins, a Grant County lawyer, by a margin of more than 20 percent.
Massie, who was supported by Republican U.S. Sen. Rand Paul, reported raising nearly 10 times as much money as Adkins, according to the Federal Election Commission.
David Lewis, an anti-abortion activist who ran as an independent, finished a distant third.
There were no surprises in races for the state's Congressional races outside Central Kentucky, with incumbents winning re-election in the 1st, 2nd, 3rd and 5th Districts.
Incumbents piled up huge spending advantages over what amounted to token candidates in some cases.
In Western Kentucky's 1st District, incumbent Republican Ed Whitfield easily defeated Democrat Charles K. Hatchett.
In the 2nd District, incumbent Republican Rep. Brett Guthrie won a third term by turning away perennial candidate David Lynn Williams, a Democrat; Libertarian Craig Astor; and Andrew Beacham, who ran as an independent to showcase his militant anti-abortion views.
U.S. Rep. John Yarmuth of Louisville, who had been one of only two Democrats in the state's congressional delegation, easily defeated Republican Brooks Wicker and Robert DeVore, who ran as an independent, to keep his 3rd District seat.
With the defeat of Ben Chandler in the 6th District, Yarmouth is now the only Democrat in the state's delegation.
In the 5th District, which covers Southern and Eastern Kentucky, Rep. Hal Rogers defeated Manchester lawyer Kenneth Stepp by a margin of about 3 to 1 to win a 17th term.
Stepp reported spending only $589 as of mid-October. Rogers reported spending $1.1 million during the election cycle, giving much of it to other campaigns.