One northbound land of Interstate 75 remained closed early Tuesday afternoon at a crash scene in Rockcastle County.
Both southbound lanes have been reopened at the crash site just north of the Mount Vernon exit, Kentucky State Police said.
The interstate were closed both north and south about 4:30 a.m. Tuesday, after a crash involving a tractor-trailer carrying 55-gallon drums of a chemical used in stripping paint.
Public information officer Steven Douglas, with Kentucky Commercial Vehicle Enforcement, said James A. Key of Tryon, N.C., lost control of the rig, left the road and crashed just off the right shoulder.
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Key was treated for injuries while haz-mat crews worked for several hours to remove debris and reopen the highway, Douglas said.
Drugs and alcohol are not suspected in the wreck, Douglas said.
The trailer apparently separated from the rest of the truck when it crashed, Douglas said.
The vehicle was carrying methylene chloride, which required handling by hazardous-materials workers. Apparently, only a few barrels were on the truck, and the danger was not considered serious for nearby residents, Douglas said.