The city of Danville expected to run out of water by midnight Tuesday, and the city of Hustonville already was without water Tuesday night.
Danville residents also are without power.
Power to the pump station at Lake Herrington is out, and Kentucky Utilities has been unable to find the downed lines to repair them.
City Clerk Donna Peek, who was working at the city's emergency operations center, said she did not expect city residents to have water until at least 10 a.m. or noon Wednesday.
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Once water is restored, she said it will be with a boil water advisory.
The city was having generators brought in from Nashville and Atlanta, and KU crews were standing by to help get them going, Peek said.
Those generators were expected to arrive at 2 a.m. and 8 a.m. Wednesday.
Downed trees and power lines also led the city of Danville to close streets Tuesday evening to all travel except for emergency vehicles. Peek said the restriction will also remain in place for at least part of Wednesday morning.
"There's trees everywhere," she said. "They're popping."
The Boyle County Health Department and Perryville Baptist Church were providing shelter to residents Tuesday night and would remain open "as long as they can keep power," Peek said.
She said three other shelters had had to close because they lost electricity.
Restaurants in Danville will be closed Wednesday because of the lack of water, and Peek said the city hopes other businesses that use a lot of water will also remain closed.
The Ephraim McDowell Regional Medical Center is still operational. It had some water reserves and was using bottled water, Peek said.
Some nursing home residents were moved to shelters because of the power outages, Peek said.
A backup generator provided electricity at BHI Assisted Living, said Stacy Evans, manager.
She said the facility had some bottled water on hand and also had "water stored in all the pots and pans we can get."
She said several of the home's 10 residents were spending the night in the living room; others' families had picked them up and taken them to other locations.
Evans said the facility was "trying to keep them comfortable and make sure that they don't get too cold."
KU spokesman Cliff Feltham said the bad weather prevented the company from using a helicopter to pinpoint the location of the problem.
He said about 7,000 customers in Boyle County were without power Tuesday night.
Most of Berea in Madison County was without power Tuesday afternoon because of a power grid outage in the area.
The outage affected nearly all of Berea's 10,000 residents, said Michael Bryant, deputy director of Madison County emergency management agency.
"They've got their hands full," Bryant said.
All of southern Madison County could also be without water Wednesday, unless power is restored, said Michael Eirich, operations manager for Berea Municipal Utilities.
"We're in a bad spot," Eirich said. "We can't get the word out to the customers not to use any water."
At 10:30 p.m., he said the city had enough water to last about 15 to 20 more hours.
KU officials said it would be sometime Wednesday before electrical service is restored and the water plant is operational again.
Eirich said the water plant in Berea serves 25,000 to 30,000 customers in southern Madison County.
Berea officials asked citizens to stay off roads unless absolutely necessary and treat all intersections like four-way stops since the traffic lights are out, according to a news release from Madison County.
Officials set up a temporary shelter at Church on the Rock on U.S. 25 near the outskirts of Berea.
In the rest of Madison County, 3,400 customers did not have power. Those customers included Berea Municipal Services. (The city counts as just one customer for KU.)