What we'll see
The Reds and Cardinals close their three-game series in Cincinnati (1:10 p.m., Fox Sports Ohio) with the knowledge they'll meet again only three more times this regular season — the final three games of the year in St. Louis.
The U.S. Open tennis tournament begins with Roger Federer and Victoria Azarenka holding the No. 1 seeds (1 p.m., ESPN2)
The 2012 college football season kicks off with a couple of matchups that matter. No. 9 South Carolina visits Vanderbilt (7 p.m., ESPN), and Mike Leach makes his Washington State debut at BYU, his alma mater. (10:15 p.m., ESPN)
The first full Saturday of college football provides variety for all tastes: The throwback throwdown (Notre Dame vs. Navy in Dublin, Ireland, 9 a.m., CBS-27); the intrastate rivalry (Marshall at No. 11 West Virginia, noon, FX); the BCS buster (No. 8 Michigan vs. No. 2 Alabama, 8 p.m., ABC-36), and the guarantee-game blowout (Arkansas State at No. 5 Oregon, 10:30 p.m., ESPN). But don't forget the upset special (Eastern Kentucky at Purdue, 3:30 p.m., Big Ten Network).