LJ Stegall, the reigning Mid-South Conference Special Teams Player of the Week, rushed for 146 yards and three TDs as Reinhardt rallied to upset host Lindsey Wilson despite a record night from Blue Raider quarterback Branden Cresap.
Ian McIntosh scored the go-ahead TD for Reinhardt with 1:35 left to play. Lindsey Wilson's comeback hopes were dashed when Cresap's pass intended for Chaz Barnes was intercepted by Richard Wilburn at the 1:09 mark.
Cresap, a senior who starred at Collins, threw for five TDs and a school-record 490 yards. His five TD passes matched the school mark he previously set.
The Blue Raiders, ranked 18th in the preseason NAIA coaches' poll, stormed out to a 20-0 lead, but the Eagles answered with 24 straight to get back into the game with 3:54 left before halftime.
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Turnovers were the Blue Raiders' undoing. They lost three fumbles and had two interceptions while forcing just one Reinhardt fumble on the afternoon.
Cortez Barber (Warren Central) finished with eight receptions for 128 yards and two TDs.
Morehead St. 49, Pikeville 36: Sophomore quarterback Austin Gahafer threw for 277 yards and five TDs as the Eagles easily avenged their 13-10 loss at home to the Bears last season.
Gahafer, a St. Xavier graduate, finished 30-for-43 with no interceptions.
Cyrus Strahm caught eight passes for 77 yards and two TDs for the Eagles.
The Bears' Seth Millar, a transfer from Georgetown College, rushed for 130 yards and four TDs on 15 carries.
Wesley 35, Thomas More 20: Host Wesley, the fifth-ranked team in NCAA Division III, bested the No. 22 Saints in the opener for both schools. Wesley in one stretch scored four unanswered TDs.
Goose Cohorn (Dixie Heights) caught seven passes for 101 yards and two TDs for the Saints.
Cumberland 34, Cumberlands 27: The host Bulldogs, ranked No. 25 in the preseason NAIA coaches' poll, came out on top in the regular-season and Mid-South opener for both teams despite accumulating nearly 100 fewer yards than the No. 4 Patriots.
Anthony Knight returned an interception 74 yards for a TD with 13:17 left to put the Bulldogs up 27-20. Michael Green rushed 61 yards for a score eight minutes later to give the hosts a two-TD advantage.
Centre 42, Hanover 17: The Colonels scored three unanswered TDs after yielding a first-quarter field goal and never trailed in both teams' season opener.
Ky. Christian 30, Bethel 9: The Knights held the Wildcats to just 160 yards of offense while manufacturing 415 total yards en route to a road win in the MSC opener for both teams.