Opportunity kept a knock-knock-knockin' Wednesday, but Kentucky couldn't prod itself to answer the door.
The Wildcats left runners on base in every inning except the ninth — 12 runners total — as second-ranked Louisville came into Cliff Hagan Stadium and took a 5-2 victory before a crowd of 3,044.
The win gave the Cardinals a two-game season sweep, having won 2-1 in 10 innings last week.
"We had plenty of opportunity to score some runs and actually score a few runs," UK Coach Gary Henderson said. "But we weren't able to take advantage of it.
"That, and the sixth inning is really the entire game. They were able to take advantage of the extra outs and the extra bases in the sixth. And when we had the opportunities, we didn't do a good job of driving guys in."
For the Cats (26-21), Wednesday's game capped a string of eight straight games against top 10 programs — the toughest eight-game stretch in program history. UK finished the stretch 3-5.
"We've got some guys that are certainly playing better as the season goes," Henderson said. "We've got some guys that are in a rough spot right now. But I think any time you play good people, you learn things about your kids.
"The game got going fast for some of them tonight; that was pretty clear. So what you hope is you keep running them out there and they develop the ability to slow the game down a little bit."
Perhaps UK will meet U of L for a third time this season — if an NCAA regional berth pans out.
"I'd absolutely love it," said UK right fielder Dorian Hairston, whose brother Devin is U of L's shortstop. "I mean, we're real competitive. They got us twice this year but, hopefully, if we do end up in that regional, I think we'll be better prepared to do something special."
Louisville (38-11) took a 1-0 lead in the third.
Mike White greeted UK reliever Dylan Dwyer with a double to right field. Nick Solak drove White in with a single up the middle.
UK stranded runners at second and third in the first and third innings.
Then, in the fourth, the Wildcats loaded the bases with none out.
Sean Leland came out of the Louisville bullpen to strike out Riley Mahan.
One run scored when left fielder Mike White dropped Evan White's fly ball, which would have been deep enough for a sacrifice.
One out later, JaVon Shelby drew a bases-loaded walk to give UK a 2-1 lead.
Leland escaped further damage, getting Dorian Hairston to ground out.
The Cardinals broke through with four two-out runs in the sixth.
One scored on Mike White's bases-loaded walk. Two more came in on a two-base fielding error, a hard-hit Solak grounder that eluded second baseman Shelby. And a final run crossed on a wild pitch.
"The game came down to who was going to get a two-out hit," U of L Coach Dan McDonnell said. "They had good opportunities, and we were fortunate to get out of those jams. And we had several opportunities, and fortunately Solak had a really quality at-bat there, and I think that was the game."
Solak and Will Smith each finished with two of U of L's nine hits.
Thomas Bernal had two of UK's six hits.