Southwestern handed Madison Southern its first defeat of the season, but of greater concern to the Eagles coming out of Friday night's game in Somerset was an apparent injury to high-profile running back Damien Harris.
Harris suffered an apparent injury to his right leg near the end of the first half, according to WKYT. Harris did not play in the second half for the Eagles (5-1). Multiple images on Twitter showed an ice bag wrapped around the senior running back's right leg.
After the game, at 10:26 p.m., Harris tweeted the following: "Minor set back for a major comeback. We gonna come back better than ever #OneSquadOneGoal #MadSouth"
Madison Southern coach Jon Clark could not immediately be reached for comment.
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Before leaving the game, Harris rushed 12 times for 120 yards, passing Shaun Alexander for 15th all-time in state career rushing yardage. He scored on a 94-yard kickoff return and rushed for TDs from 53 and 14 yards out.
Harris, the nation's top running back, lists Kentucky among his top five along with Alabama, Ohio State, Texas A&M and Florida. He was scheduled to visit Lexington for UK's game versus South Carolina on Saturday night.
Madison Southern is scheduled to host undefeated Pulaski County in a nationally televised game on ESPNU next Friday night designed to showcase Harris.
The Warriors (5-2) avenged a 44-6 loss to Madison Southern last year with the 32-26 win.
No. 18 Dixie Heights 43, Tates Creek 6: Drew Moore rushed for 115 yards on only seven carries as the Colonels smoked the host Commodores.
Moore also went 4-for-7 for 58 yards and two TDs for Dixie Heights (5-1).
The Commodores (3-4) were held scoreless until Max Sweet's 1-yard TD run with 4:46 left in the game. Sweet finished with 52 rushing yards.
No. 24 Anderson Co. 35, Woodford Co. 7: Senior Chris Toomey scored TDs on both sides of the ball in the host Bearcats' victory.
Toomey recovered a fumble for a 2-yard score in the second quarter to put the Bearcats (4-2) up 21-0. His 27-yard TD catch in early stages of the third period was Anderson quarterback Zach Carmichael's lone complete on the night (1-for-7).
Kaine Maxberry paced the Yellowjackets (1-5) with 96 yards and a TD on 13 rushes.
East Jessamine 39, Franklin Co. 21: The host Jaguars scored the first 20 points and never trailed in the upset of the Flyers.
Chris Mastin rushed for 115 yards and two TDs for the Jaguars (2-3), No. 32 of the 40 teams ranked in the Class 5A Cantrall Ratings.
Landon Hurst returned a kickoff 85 yards for a Franklin TD with 7:58 left in the game and finished with a game-high 182 all-purpose yards for the Flyers (4-2), the sixth-ranked squad in Class 5A.
No. 7 St. Xavier 35, Trinity 21: The Tigers (6-2) defeated the city rival Shamrocks (4-3) for the first time since 2009.
The Shamrocks are off to their second straight 4-3 start to a season.
Graves Co. 28, No. 9 McCracken Co. 21: Joey Marshall returned a fumble 29 yards for a TD and the Eagles (3-3) converted a two-point attempt with 2:36 left to upset the host Mustangs (5-1).
No. 2 Highlands 46, Harrison Co. 13: Beau Hoge, a senior quarterback, threw six TD passes — including two to fellow seniors Alex Veneman and Justin Weyer — in the romp for the Bluebirds (6-0).
No. 5 Simon Kenton 45, Campbell Co. 14: Logan Winkler returned the opening kickoff 88 yards for a TD and had receiving TD for the host Pioneers (7-0).
Simon Kenton has yet to allow more than 17 points on the season and is holding its opponents to an average of 10.1 points per game.
Taylor Co. 30, Marion Co. 8: Senior running back Jarrett Benningfield rushed 15 times for 122 yards and three TDs as the host Cardinals (2-4) overcame the Knights (4-2).
Franklin-Simpson 14, Warren East 13: Josiah Robey's only completion of the night was a 51-yard game-winning TD to Colton Hurt to propel the Wildcats (5-1) past the Raiders (3-4).