Jay Coleman rushed for touchdowns on host Paul Dunbar's first two possessions and set the stage for a city upset on Friday night.
Then Bryan Station (6-2) scored 28 points over a seven-minute, 11-second stretch spanning the second and third quarters and held on for a 28-20 win.
Andre Davis scored Bryan Station's first TD from 3 yards out with 4:32 left in the second quarter.
Dunbar (3-4) went three-and-out on its ensuing possession and had its punt blocked and recovered by Bryan Station at Dunbar's 19-yard line.
Never miss a local story.
Davis threw a 22-yard TD pass to CJ Walker with 1:10 remaining in the half to knot the game at 14.
Trey Penney threw an interception on the first play of Dunbar's next possession.
The Defenders' drive started with a minute left in the half and ended in a 2-yard TD run by D'Andre Mack with 29 seconds left.
Bryan Station scored on its first possession in the second half — a 2-yard TD by Davis with 9:21 to play in the quarter — to cap its rapid run.
Davis rushed for 56 yards and two TDs. He went 7-for-14 for 190 yards and one score.
Dunbar outgained Bryan Station 326-107 on the ground, and 331-297 overall.
LaDarius Morton had a game-best 137 rushing yards for the Bulldogs.
No. 12 Lafayette 28, Clark Co. 7: The Generals doubled up the Cardinals in offensive production and scored the game's final 28 points to win on the road.
Lafayette (5-3) finished with 288 total yards to Clark's 140.
Malik Robinson rushed for 153 yards and a TD — an 87-yard exclamation point in the fourth quarter — on 13 carries for the Generals. The senior — a linebacker on defense — also returned a fumble recovery 61 yards for a TD in the third quarter.
Madison Central 41, Tates Creek 21: Korrion Crier and Johan Williams each eclipsed 100 yards and had two TDs in the Indians' win.
Crier had 187 yards on the ground for the Indians (3-5), while Williams finished with 114.
Langston Love had 150 yards and two TDs on five carries for Tates Creek (3-5).
Lexington Catholic 13, Taylor Co. 8: The Knights (5-3) held off the host Cardinals (2-5) to win their fourth straight.
Pulaski Co. 35, Madison Southern 0: The Maroons (7-0) stayed undefeated while the Eagles dropped their second straight after losing star running back Damien Harris to injury. ESPNU reported during its broadcast of the game that Harris suffered a sprained MCL last Friday and will be out 3-4 weeks. The extent of Harris' injury was not previously made public.
Ryle 21, No. 14 Covington Catholic 14: Colin England rushed for 221 yards and a TD in the host Raiders' upset of the Colonels (3-4).
Ryan Rytlewski, a senior quarterback, rushed from a yard out for the game's final score with :36 left in the third quarter to give Ryle (3-5) the edge.
Franklin Co. 14, Woodford Co. 6: The Flyers came out on top of a game in which both teams combined for only 15 first downs and neither cracked 200 yards of total offense.
Franklin (5-3) finished with 152 yards and six first downs. Landon Hurst rushed for a Franklin-high 35 yards, or 23 percent of the Flyers' total offense, and a TD in the win.
Barrett Sanderson, Franklin's junior quarterback, connected on five of his six pass attempts for 56 yards — including a 31-yarder to fellow junior Jhanny Rodriguez.
The Yellowjackets (1-6) finished with 194 yards — 185 of which came via rushing — and nine first downs.
Junior running back Emir Bernabe had a game-high 105 yards and scored Woodford's lone TD.
Anderson Co. 36, West Jessamine 0: Ryan Martin rushed for two TDs and caught another as the Bearcats (5-2) won their fourth straight.
Zach Carmichael led Anderson with 95 rushing yards. He went 2-for-4 for 81 yards and a TD.
The Colts (1-6) fell for the third straight game. Daniel Snider led them with 52 rushing yards.
Central Hardin 34, Collins 9: Xavier Arnette rushed 25 times for 181 yards and three TDs as the Bruins remained undefeated (7-0).