If nationally ranked Marion County wins the 5th Region as expected, the Knights will help raise the curtain on the Girls' Sweet Sixteen in Bowling Green this year.
The 5th Region will play the 4th Region in the opening game of the Houchens Industries/KHSAA State Tournament on March 13 in Western Kentucky University's Diddle Arena.
The pairings were determined by a draw conducted by the KHSAA on Friday.
Marion County, state runner-up last year, has been unbeatable so far this season. Led by Kentucky signees Makayla Epps and Kyvin Goodin-Rogers, the Knights are 22-0, and their closest wins have been by 15 points over defending champ Manual and 16 over Mercy.
The 4th Region's highest-rated teams are No. 13 Monroe County and No. 17 Bowling Green.
The 11th Region, home to No. 7 Madison Central, drew into the last game of the first round on March 14. The 11th Region is matched against the 9th Region, whose highest-rated teams are No. 8 Highlands and No. 9 Notre Dame.
The 6th and 7th regions, made up mostly of Louisville schools, are paired against each other in the first round. That could mean a showdown between No. 11 Mercy against either No. 4 Manual, No. 5 Ballard or No. 9 Assumption.