Patrick Towles threw two TD passes and ran for another score and host Highlands, ranked No. 1 in Dave Cantrall's Rating the State, held off a late rally by No. 21 Covington Catholic.
Corey Compton scored twice for the Bluebirds, the first on an 80-yard pass from Towles and the second on a 3-yard run that gave Highlands (8-0) a 20-0 lead.
Paul Ritter's 99-yard kick return to start the third quarter got Covington Catholic (4-4) its first TD and cut the lead to 20-10, but Towles' second TD pass on the next drive pushed the Bluebirds' lead to 27-10.
Evan Talker's second field goal and Blake Bir's fourth-quarter TD pass cut the Bluebirds' lead to 27-20 with 4:32 to play, but Highlands went on to its 36th straight victory.
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Anderson Co. 38, South Oldham 37: Seth Carmichael threw four fourth-quarter touchdown passes and Anderson County scored 28 unanswered points in a come-from-behind win at South Oldham.
The Dragons had scored 30 points in the third quarter in a variety of ways — on a run, an interception return, a fumble return, a safety and a pass — to build a 37-10 lead.
Carmichael finished with 297 passing yards and 91 rushing yards on 16 carries.
No. 2 Trinity 49, No. 16 Eastern 0: Derek Bishop ran for 201 yards and three scores, and sophomore Dalyn Dawkins ran for 115 and two TDs in a rout at Eastern.
No. 15 Henry Clay 70, Madison Central 30: Vinny Miller had two TD passes and ran for two scores as both squads lit up the scoreboard at Henry Clay. The Blue Devils scored 21 points in each of the first three quarters. Blake Green had two TD catches for Henry Clay and Jamez Chenault scored twice for the Indians.
Lafayette 35, Bryan Station 25: Matt Britt threw three touchdown passes to Tanner Napier and another to Nick Jeter in the Generals' home victory. LJ Warfield had two TD runs for the Defenders.
Lexington Christian 38, Raceland 26: Scout McCamy had a TD pass and he, Sam Maybriar and Clay Mossbarger each had a TD run in the Eagles' victory at Raceland.
Scott Co. 53, Paul Dunbar 7: Kevo Edwards ran for 1- and 32-yard scores to get the Cardinals started and Dieries Dumphord and Alex Caldwell added two TD runs and passes, respectively, in a victory against visiting Paul Dunbar.
No. 3 Bell Co. 70, Madison Southern 7: John Hilton ran for 157 yards and two touchdowns on 11 carries in host Bell County's rout of Madison Southern. Ben Madon and Ryan Collett both also had a pair of TD runs for the Bobcats (8-0).
Hazard 57, Jenkins 0: John Combs threw four touchdown passes to four different receivers to help host Hazard (8-0) remain undefeated. Austin Johnson caught one of those TD passes, a 58-yarder, and threw another, a 16-yard score to B.J. Combs.
Pikeville 47, Betsy Layne 20: Led by quarterback Randy Maynard's two TD runs, the Panthers locked up the district title at home. Maynard ran 208 yards on nine carries.