John Hardin won its 10th consecutive season opener, routing Henry Clay 56-6 in the Don Franklin Bowl at Lindsey Wilson in Columbia.
John Hardin totaled 489 yards on the ground, led by Jeremy Harness' 306 yards on 11 carries.
Harness, a 5-foot-8 senior tailback, averaged 27.8 yards per rush and scored on four long runs that covered 33, 53, 33 and 39 yards.
Quinsie Brown added a pair of TD runs and had 65 yards on seven carries.
Henry Clay's lone score came on a 61-yard run by David George.
Highlands 35, Boyle Co. 14: Boyle County's 30-game winning streak is history.
Visiting Highlands shut out the Rebels in the second half and held their top rusher, Devon Cox, to zero second-half rushing yards.
"It feels awesome," Highlands senior quarterback Patrick Towles told the Cincinnati Enquirer. Towles had three rushing touchdowns, two in the third quarter to complete the scoring.
Lafayette 50, Mason Co. 0: William Johnson ran for two touchdowns and scored another on a punt return and the Generals cruised past host Mason County in the Meadowview Regional Kickoff Classic. Jeremy Smith added a pair of TD runs.
Mason County running back/linebacker Josh Harris, who has committed to play at Kentucky, ran for 32 yards on 11 carries.
Lexington Catholic 33, Bell County 27: Lexington Catholic forced four turnovers and beat Bell County on the road in a rain-soaked contest that included a 45-minute weather delay.
Junior quarterback Kyle Bowlin went 11-for-20 for 216 yards and two touchdowns for the Knights, who allowed 423 rushing yards. Bell County senior Corey Davenport rushed for 258 yards and two touchdowns.
Franklin Co. 63, Nelson Co. 35: The Flyers scored four TDs in each of the first two quarters to build a big lead against visiting Nelson County.
Franklin County sophomore Chris Roberts scored four touchdowns and ran for 141 yards on 11 carries. Junior Ryan Timmons added three TDs, two rushing and one receiving.
Dylan Beasley threw for 440 yards and three TDs for Nelson County.
Newport Central Catholic 42, Dixie Heights 13: Thoroughbreds quarterback Brady Hightchew threw three touchdown passes and ran for another score to help his team defeat shorthanded host Dixie Heights.
The Colonels were missing star quarterback Zeke Pike. The Auburn commitment served a one-game suspension for an ejection from a playoff game against Highlands last season.
Seth Bruns had a 99-yard kickoff return for a touchdown for Dixie Heights.
Breathitt Co. 53, Estill Co. 6: Junior quarterback Richard Trent threw for two touchdowns and ran for three more as the Bobcats jumped out to a 34-0 lead at halftime.
Senior tailback Will Collins ran for 171 yards and a TD.
Covington Catholic 42, Campbell Co. 2: Colonels quarterback Blake Bir had four touchdown passes in a rout of host Campbell County. Charlie Mader was on the receiving end of two of Bir's TD throws.
Gabe Gray ran for 100 yards and a TD.