One person was killed about 2 a.m. Tuesday in a Lincoln County crash on U.S. 150, according to police.
The crash occurred just north of Stanford, near Ky. 3258, WKYT reported.
The other person involved in the crash was flown to University of Kentucky Chandler Hospital, according to WKYT. Names were not released.
State police told WKYT that alcohol may have been a factor in the crash.
The westbound lanes of the highway, which were closed for clean up, reopened about 4:30 a.m.