It may be "over the river and through the woods in snow" this week, said WKYT Chief Meteorologist Chris Bailey.
He said travel could be affected over much of the eastern half of the country by an incoming winter storm.
A light wintry mix of sleet and snow was expected to move into Central Kentucky Tuesday night.
In preparation for that, crews in Lexington began pretreating bridges and overpasses with salt and brine on Monday, and the Transportation Cabinet said crews would report for duty at 4 a.m. Tuesday to begin treating roads throughout Central Kentucky if needed.
Bailey said the sleet and snow would switch over to rain during the day Tuesday, but that by Tuesday evening, a band of snow would be moving in.
On Tuesday night and during the day Wednesday, Bailey said, much of the area could get "at least a few inches" of snow.
Wednesday's high will be in the 20s, and winds could reach 20 or 30 miles per hour.
"It will feel like it's down in the single digits at times," Bailey said.
He said Thursday should be dry, but temperatures Thanksgiving morning will be in the lower teens, with highs reaching into the low 30s Thursday afternoon.
And Bailey said more wintry precipitation is probably on the way.
"I think we'll have several more snows before Christmas," Bailey said. "We're kind of locked in a little pattern right now."