The southbound lanes of Interstate 75 between Jellico and Caryville, Tenn., will be closed at least until Thursday, highway officials announced.
A section of the embankment supporting the road collapsed in early March, but crews had reopened one southbound lane.
However, there was a further slide during heavy rain Monday night, and officials closed the road again, said Mark Nagi, a spokesman for Tennessee Department of Highways.
The southbound side of the busy road will be closed until Thursday, and the northbound side will be reduced to one lane as crews work at the site, at mile marker 143, according to the Kentucky Transportation Cabinet.
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Drivers should be careful in the area and expect long delays.
Here are potential detours for I-75 south:
■ Take Exit 160 in Jellico, follow US 25W to LaFollette and back onto I-75 South at Exit 134 in Caryville.
■ Wide loads should take Exit 160 in Jellico, turn right and follow SR 297 West to SR 63 and back onto I-75 South at Exit 141.
■ People traveling to destinations along I-40 east of Dandridge, Tenn., should take Exit 29 at Corbin, Ky., follow U.S. 25E to Morristown, Tenn., and take I-81 South to its junction with I-40.