Nearly two inches of snow slowed traffic Tuesday and prompted Fayette County Public Schools to dismiss an hour early.
Snow started to fall at mid-morning Tuesday in Lexington and was expected to continue into the afternoon.
Before noon, several wrecks were reported in Lexington.
Snow and single-digit wind chills were expected Tuesday, according to a National Weather Service winter weather advisory.
One to three inches of snow are possible for areas from west of Louisville to Richmond and Winchester and farther north. Counties to the south were expected to get about an inch of snow.
Lexington road crews treated several streets Monday night and were out plowing as the snow fell Tuesday, mayor's spokeswoman Susan Straub said.
Lexington police said conditions at 11 a.m. were "pretty slippery" on Lexington streets, and traffic was moving slowly. They reported 41 non-injury collisions and one minor-injury collision from 10 a.m. to noon.
Motorists should slow down, leave early, expect delays or "stay home if you can," said police Lt. Doug Pape. Fans coming downtown to the University of Kentucky-Mississippi State game Tuesday night should "leave early and expect parking to be hard to find."
West winds of 15 to 25 mph with higher gusts Tuesday afternoon will cause the dry, fluffy snow to blow around. This could create travel problems on north-south roads, including interstates 65 and 75, according to the weather service.
Also, temperatures are expected in the 20s, but it will feel even colder. Wind chills are forecast to go as low as 5 degrees by mid-afternoon.
The advisory is in effect until 7 p.m.