James Blackmon Jr. scored 26 points and Indiana used a big run in the second half to get past No. 22 SMU 74-68 on Thursday.
The Hoosiers are 3-0 for the fifth straight year.
SMU (1-2) lost its second straight road game. The Mustangs were led by Ben Moore with 16 points and Nic Moore with 13 on a topsy-turvy night.
SMU started both halves by taking leads, only to see Indiana come back both times.
Sign Up and Save
Get six months of free digital access to the Lexington Herald-Leader
The Mustangs erased Indiana's 38-33 halftime lead by starting the second half on a 10-0 run. But just when it looked as if SMU might pull away, the Hoosiers rallied with an 18-5 burst.
Blackmon's 3 from the top of the key with 8:56 left gave Indiana a 53-52 lead, and when Nick Zeisloft hit another 3 with 4:51 to go, Indiana led 63-55.
Tennessee 70, Texas Southern 58: Josh Richardson scored 19 points and pulled down eight rebounds as Tennessee gave new coach Donnie Tyndall his first home win.
The Volunteers (1-1) won their 23rd consecutive home opener and avoided their first 0-2 start since 1965-66. Tennessee had opened the season Friday with an 85-69 loss to No. 15 VCU at Annapolis, Md.
Kevin Punter added 13 points, Armani Moore scored 11 and Willie Carmichael had 10 for Tennessee. Punter and Richardson each shot 3 of 5 from 3-point range.
David Blanks scored 14 points, Deverell Biggs had 12 and Chris Thomas added 11 for Texas Southern (0-3).
Texas Southern hung with Tennessee for much of the night and actually led 41-40 when Tonnie Collier's 3-pointer capped an 8-0 run with 13:21 left. Tennessee went ahead for good on Punter's 3-pointer with 12:14 remaining and eventually wore down the Tigers.
Vanderbilt 72, Lipscomb 62: Damian Jones, a preseason All-Southeastern Conference first-team selection, scored points 21 and had six rebounds. Luke Kornet and Walter Baldwin IV added 11 points each for the host Commodores.
Kornet's father, Frank, was a star at Lexington Catholic and Vanderbilt and played in the NBA for the Milwaukee Bucks.
Lipscomb (1-2) narrowed the deficit to 52-49 on Martin Smith's foul shot with 10:08 left, but Vanderbilt's Jeff Roberson and Baldwin answered with back-to-back 3-pointers.
The Commodores (2-0) started three freshmen and two sophomores against the Bisons, members of the Atlantic Sun Conference.
Vanderbilt dominated inside, outscoring Lipscomb 30-18 in the paint.
South Carolina 69, Cornell 45: Sindarius Thornwell scored 13 of his 14 points in the opening half as South Carolina built a double-digit lead and rolled to 69-45 victory over Cornell to close the opening round of the Charleston Classic on Thursday night.
Mindaugas Kacinas had 10 points and 11 rebounds for his third career double-double.
The Gamecocks (2-1) will face Charlotte on Friday for a spot in Sunday's championship. The 49ers outlasted Penn State 106-97 in double overtime earlier Thursday.
JNo. 10 Texas 71, Iowa 57: Jonathan Holmes scored 17 of his 19 points in the second half and Isaiah Taylor added 15 to lead Texas past Iowa in the 2K Classic in New York.
The Longhorns trailed by 12 points in the first half but outscored Iowa 47-27 in the final 20 minutes to advance to the championship game Friday at Madison Square Garden against No. 23 Syracuse or California.
Texas (3-0) didn't take its first lead until early in the second half following Holmes' blistering start out of intermission. Holmes and Taylor helped the Longhorns keep the tempo up and put it away a little over midway through the half.
The Longhorns play at Kentucky Dec. 5.
Georgetown 74 Cumberland 54: The host Tigers took control in the second half. Georgetown miscues helped the Bulldogs build an early lead, but Georgetown went on an 8-0 run and never looked back.
Gerard Coleman had a game-high 19 points, and Deondre McWhorter chipped in 18 points with nine rebounds.
Campbellsville 54, Cumberlands 54: Eric Gaines intercepted a pass near midcourt and threw down a fast-break, one-handed jam with 25 seconds remaining to lift No. 19 Campbellsville past No. 25 University of the Cumberlands.
Cumberlands' Xavier Owens forced a short jumper at the buzzer, but the ball bounced off the rim.
Gaines, a senior from Chicago who missed the first week of the season because of an injury, finished with 15 points and 12 rebounds.
No. 12 Louisville 95, Belmont 35: Freshman Mariya Moore scored 17 points, her average through her first three games, and led five players in double figures.
Sara Hammond had 13 points for Louisville. The Cardinals hit 58.7 of their shots from the field while Belmont hit just 26.9 percent.
Cumberland 63, Georgetown 55: Cumberland rallied for a 14-edge in the second half as Brittany Lawson led the way with 16 points.