LOUISVILLE — Amile Jefferson scored 19 points and Jahil Okafor added 18 Saturday as fourth-ranked Duke handled No. 6 Louisville 63-52 in the KFC Yum Center.
Tyus Jones added 10 points for the winners, who made 21 of 43 shots (48.8 percent).
Louisville had shooting woes all day, going 18 of 61 (29.5 percent).
Terry Rozier led the Cardinals with 17 points. Montrezl Harrell added 10 points and 14 rebounds.
The Blue Devils (15-2, 3-2 Atlantic Coast Conference) snapped a two-game skid. The win was the 998th of Coach Mike Krzyzewski’s career.
Duke leads the all-time series with U of L 6-4.
Louisville dropped to 15-3 overall, 3-2 in the ACC. The Cardinals’ first conference loss came a week earlier, 72-71 at North Carolina.
Duke had an 11-0 run en route to a 30-20 halftime lead.
Louisville outrebounded the Blue Devils 22-17 but couldn’t find the basket on a regular basis. The Cards shot just 22.6 percent (7 of 31), while Duke made 46.2 percent (12 of 26).
Duke led 15-14 before scoring the next 11 points.
Jefferson started things with a free throw, and Tyus Jones followed with a steal-and-layup.
A Jefferson jumper preceded a three-point play by Justise Winslow.
Quinn Cook finished the flurry with a three-pointer that just beat the shot clock.
Duke opened the second half with seven quick points — a three-pointer by Cook, a low-post bucket by Okafor and two free throws by Jones — to open a 37-20 lead.
The lead grew to 41-26 before Rozier energized the Cardinals with seven straight points, cutting the deficit to 46-32.
A pair of Rozier free throws later pulled the Cardinals to within 11, 56-45, with 2:31 left.
Rozier drained a three-pointer with 1:27 left to make it 58-48.
That’s as close as U of L would come, though.