Louisville junior Kelsi Worrell set an American record in the 100 butterfly in the preliminaries, and she topped that time while winning in the finals in the NCAA women's championships in Greensboro, N.C.
Worrell, the first American woman to swim the event in under 50 seconds, was timed at 48.89 in the preliminaries and 49.81 in the finals, giving Louisville its first female NCAA swimming champion.
"I just want to give all the glory to God, I wouldn't be here without him," Worrell said. "I want to thank all my teammates. I have so many family members in the stands and I am just so grateful that they are here and that I get to share this with them."
Swimming legend Natalie Coughlin previously held the American 100 butterfly record at 50.01.
Kentucky's Caroline Bechtel was sixth in the 100 butterfly, finishing in 51.68 seconds.
The Cardinals' 200 medley relay squad — Worrell, Andrea Kneppers, Tanja Kylliainen and Andrea Cottrell — finished second to California. Cal won in 1:35.15, followed by Louisville (1:35.75) and Tennessee (1:36.29).