Kentucky sophomore shortstop Chris Wade hit a one-out, game-winning home run in the top of the 11th inning, giving the Cats a dramatic, come-from-behind 5-4 win over host New Orleans (5-12) on Tuesday night.
UK had trailed throughout the game and scored a run in the eighth and ninth innings to tie the game.
It was the third home run of the season for Wade, who sent a 2-0 offering and over the left-field fence.
Kentucky (13-4) trailed 4-3 and was down to its last strike in the top of the ninth inning before tying the game when Chris Bisson scored on a wild pitch by New Orleans closer Donnie White.
Outfielder Troy Frazier had four hits, including two doubles, for the Cats.
The win improves Kentucky's non-conference record over the last two seasons to 40-3.
Next up is a three-game series against Vanderbilt, beginning Friday at 6:30 p.m. at Cliff Hagan Stadium.