All-American southpaw Drew Pomeranz carried a no-hitter into the sixth inning in Mississippi's 9-0 series-opening win over Kentucky on Friday night at Cliff Hagan Stadium.
UK (14-4) suffered a loss in its first Southeastern Conference game of the year.
Pomeranz (3-0) was brilliant throughout the game, retiring the first eight hitters he faced and not allowing a hit until the sixth inning.
The Ole Miss pitching staff combined to two-hit the Wildcats, with reliever Eric Callender tossing the final three innings to pick up his third save of the year.
The Rebels scored three runs in the fourth inning, added a run in the fifth and sixth inning, then broke open the game with a four-run seventh inning.
UK left-hander Logan Darnell (3-1) suffered the loss after going six innings and allowing eight hits and five runs, walking two and striking out six. UK then turned to freshman right-hander Jordan Cooper, who got roughed up in his first career SEC appearance, allowing four runs on three hits and two walks in his two-thirds of an inning.
UK also used freshman right-hander Sam Kidd, who threw the final 21⁄3 innings, allowing just one hit, striking out two.
Keenan Wiley and Cory Farris had the Cats' only hits of the game, with Wiley extending his hitting streak to 12 games
Andy Burns had his hitting streak snapped at a career-best 13 games.