Louisville senior Candyce Bingham had a career day in her last home game.
She scored a career-best 26 points, making 10 of 12 free throws to help No. 8 Louisville beat 15th-ranked Pittsburgh 75-51 on Saturday to secure the second seed in the Big East Tournament next week.
"It's a great way to come out, and most importantly I'm just glad we got the win," she said.
Fellow senior Angel McCoughtry added 22 points and seven rebounds.
Though she's played her last game as a Cardinal in Freedom Hall, McCoughtry and her teammates are getting ready for the post-season. Louisville will travel to play Marquette on Monday and then head to the Big East Tournament in Connecticut, which begins Friday.
"We have a lot of work to do," McCoughtry said. "Because everything after this is one-and-done, and we don't want to be a one-and-done. ... This isn't the end. This is the beginning for us."
The Cardinals never trailed and put the game away with a 15-point run in the second half, after the Panthers got within three. Pittsburgh couldn't overcome its 25 turnovers.
"I felt that we were prepared for the press," Pittsburgh Coach Agnus Beranato said. "I am just really disappointed in our turnovers. ... They had 21 points off turnovers and then had 22 points off the glass, which is unacceptable."
Thomas More 59, Washington & Jefferson 49: Top-seeded and ninth-ranked Thomas More won its third straight Presidents' Athletic Conference Championship with a victory over second-seeded and 21st-ranked Washington & Jefferson at Crestview Hills.
The Saints (26-2), who earned the conference's automatic bid to the NCAA Division III Tournament, were led by senior guard Jayme Thiem's 16 points.
Northern Kentucky 77, Lewis 56: Cassie Brannen scored 20 points and blocked three shots as Northern Kentucky clinched the Great Lakes Valley Conference East Division title at home. The Norse (25-2, 16-2) used a game-ending 16-0 run to seal the victory.
Morehead State 72, UT Martin 50: The Lady Eagles opened on an 18-0 run and secured a home game in the opening round of the Ohio Valley Conference Tournament by defeating host UT Martin. Morehead will play Austin Peay.
Murray State 80, Eastern Kentucky 60: Amber Guffey had 21 points and five assists and Ashley Hayes had 19 points and eight rebounds to lead host Murray State (21-7, 16-2 Ohio Valley Conference) past Eastern Kentucky.
Cumberlands 72, Pikeville 53: Cumberlands (25-4, 10-2) held host Pikeville to 36.5 percent shooting and finished in a tie with Campbellsville for first in the Mid-South Conference standings.
The Patriots were led by senior Madison Flowers, who hit six three-pointers and scored 20 points. Natiera Hinton had 24 points and 11 rebounds for Pikeville.
Lindsey Wilson 80, St. Catharine 58: Senior guard Ewa Bukowska scored a team-high 17 points and added five steals for host Lindsey Wilson (23-7, 9-3 in the Mid-South Conference).
Oglethorpe 71, Centre 51: Centre was held to 28.8 percent from the field in a loss to Oglethorpe in the Southern Collegiate Athletic Conference Tournament semifinals in Conway, Ark. Chelsea Goodman scored 15 points to lead Centre.