The top-seeded Transylvania men, who were seeking their first Heartland Conference tournament title since 2009, lost to Rose-Hulman 76-73 in overtime Sunday in the finals in the Beck Center in Lexington.
Barrett Meyer, a former Franklin County standout, finished with 28 points to lead the 16th-ranked Pioneers (23-4), and Brandon Rash (Montgomery County) had 16 points and eight rebounds.
Ethan Spurlin (Lincoln County) added 14 points and 12 rebounds.
"I ache for our guys who have had a fantastic season and wanted to cut down the nets in their home gym so badly," Transy Coach Brian Lane said. "But we'll regroup."
Sign Up and Save
Get six months of free digital access to the Lexington Herald-Leader
Kentucky Wesleyan 79, Missouri S&T 59: Brandon Johnson scored 17 points and six rebounds and Kentucky Wesleyan (21-6) opened the Great Lakes Valley tournament with a victory at home.
Trinity 61, Centre 50: Centre, winner of the three previous Southern Collegiate Athletic Conference tournament titles, lost in this year's championship game in Birmingham, Ala. Jeff Mullaney, a DeSales graduate, led Centre with 11 points.
No. 16 Wisconsin 63, No. 8 Ohio St. 60: Jared Berggren scored Wisconsin's final five points — including a go-ahead three-pointer with 31 seconds left — and the Badgers beat host Ohio State.
Jordan Taylor had 19 points and Ryan Evans 10 for the Badgers, who made up for an earlier loss at home to the Buckeyes.
No. 23 Indiana 69, Minnesota 50: Christian Watford rediscovered his shooting stroke with 12 points for 23rd-ranked Indiana, and the Hoosiers blew out sputtering Minnesota in Minneapolis.
Watford, who went 0-for-13 from the floor the past two games, knocked down a pull-up jump shot and a three-pointer in the first half. He only pulled the trigger four times, but he was 7-for-7 from the free-throw line and grabbed six rebounds.
Miami: Center Reggie Johnson was declared ineligible by the Hurricanes after an investigation revealed that members of his family took travel benefits that the university said were approved by a member of former coach Frank Haith's staff. The Hurricanes have asked the NCAA for a speedy decision on whether Johnson can be reinstated.
Centre 60, Millsaps 48: Maggie Prewitt (Montgomery County) had 14 points, four assists and four steals in Centre's victory in the championship game of the Southern Collegiate Athletic Conference Tournament in Birmingham, Ala. Chelsea Benham and Paige Baechle added 12 points apiece.
Middle Tennessee 77, Western Kentucky 62: Paul Dunbar graduate Ebony Rowe and grabbed 10 rebounds to help the Lady Blue Raiders hand host Western Kentucky (8-20) the first 20-loss season in the program's history.
Alexis Govan led the Lady Hilltoppers with 22 points and Keshia Mosley had six points and 10 rebounds.
Kentucky Wesleyan 84, Saint Joseph's 73: Karly Rhoads had 19 points and 10 rebounds in the host Panthers' first-round victory in the Great Lakes Valley tournament.
Indianapolis 84, Bellarmine 56: Kylee Hamilton came of the bench to score 15 points in the Knights' first-round loss in the Great Lakes Valley tournament at Indianapolis.
No. 10 Tennessee 75, Florida 59: Glory Johnson had 21 points and 10 rebounds and host Tennessee beat Florida to secure second place in the Southeastern Conference.
The Lady Vols (21-8, 12-4) have struggled this season at times, losing at home to South Carolina and Arkansas for the first time ever. They narrowly avoided tying their regular-season loss record of nine, set during the 1996-97 season and tied by the 2008-09 squad.
No. 18 Georgia 62, LSU 46: Khaalidah Miller scored 14 points to lead Georgia over LSU, taking third place in the Southeastern Conference.
South Carolina 53, Arkansas 47: La'Keisha Sutton had 16 points and three assists for the host Gamecocks. C'eira Ricketts (Fairdale) had seven points, five rebounds, four assists and three steals for the Razorbacks.