UConn's Ryan Boatright saw the screen that left Texas forward Jonathan Holmes with an open three-pointer to beat the Huskies on Sunday.
But Boatright rolled his ankle and went to the floor while trying to switch and contest the shot.
Holmes hit the jumper from the left baseline with 2 seconds left, giving the seventh-ranked Longhorns a 55-54 win over the No. 24 Huskies.
Boatright said he suffered a "normal" ankle sprain on the play but isn't sure when he might be back on the floor. He had 24 points and seven rebounds for UConn (3-2), which lost its second consecutive game.
Digital Access For Only $0.99
For the most comprehensive local coverage, subscribe today.
Holmes had 13 points and eight rebounds to lead the Longhorns (6-0), who host Texas-Arlington on Tuesday before traveling to No. 1 Kentucky on Friday.
No. 11 Kansas 61, No. 20 Michigan St. 56: Perry Ellis had 17 points and nine rebounds to help the Jayhawks take the Orlando Classic.
Svi Mykhailiuk added 11 points and Frank Mason III chipped in 10 for Kansas (5-1).
Michigan State (5-2) got 14 points from both Denzel Valentine and Travis Trice.
No. 6 Texas 72, No. 4 Tennessee 59: Kelsey Lang scored 18 points and the Longhorns continued their torrid start and snapped a five-game losing streak in the rivalry.
The victory was another important step in Texas coach Karen Aston's mission to return the Longhorns to the nation's elite programs. Once a women's basketball powerhouse, Texas has struggled to be a factor nationally or in the Big 12 during the past decade.
Texas (5-0) had four players score in double figures and shot 62 percent in the second half.
Bashaara Graves scored 15 points for Tennessee (4-2), which has lost two in a row.
No. 7 Texas A&M 63, No. 8 Duke 59: More than 6,000 fans rose to their feet and cheered on multiple occasions while the Aggies scratched back from a 15-point deficit midway through the second half.
Despite playing without All-American senior Elizabeth Williams (injured foot), Duke appeared poised to put away the Aggies for good in leading 45-30 with 11:36 remaining.
But A&M (7-0) stuck to its game plan of relentless defense and an equally intense fastbreak to go on a 19-4 run and tie it 49-all. The teams briefly traded leads before A&M went up for good 57-55 with 3:59 remaining.
No. 12 Louisville 86, Valparaiso 59: Myisha Hines-Allen scored a season-best 19 points and had three steals, and the Cardinals rolled.
Hines-Allen scored nine points during the first half as Louisville (7-0) built a 48-24 halftime lead. Mariya Moore scored to make it 60-30 with 15:36 to play.
Sara Hammond (Rockcastle County) scored 13 points for U of L.