Starters T'laya Lyvers and Destiny Carter both were out due to illness.
No problem, though, for the team ranked 25th in the Herald-Leader pre-season coaches' poll.
Kerrigan Davis scored 16 points and Jordyn Jackson came off the bench to add a double-double of 13 points and 10 rebounds as the Blue Devils plastered Tates Creek 74-29.
"Hard work. A lot of boxing out. Taking my time on my layups," Jackson said of her effort. "We are (off to a great start). We've put a lot of work in at practice and we're really striving this year to get far."
Davis said the Blue Devils knew the pressure was on to fill in for missing players.
"Yes, sir," she said, "but it should be easy because we're very deep, and it allows everyone to step up and fill a role that they haven't yet been able to do, so that was nice."
Hannah Young added 10 points for Henry Clay (4-0), which shot 29-for-52 (55.8 percent) and committed 11 turnovers.
Hannah Hamill had six points for Tates Creek (1-3), which shot 10-for-35 (28.6 percent) and turned the ball over 24 times.
Henry Clay killed the Commodores 31-6 in points off turnovers, and 44-16 on points in the paint.
"It was a rough night," Creek Coach Tina Winn said. "What can you say? We've got to learn to play hard the whole time we're out there on the court. I have a deep enough bench that I feel I can work them hard. My thing is, this all starts in practice. The way you practice is how you're going to play. The last couple games showed how we practiced."
Henry Clay scored the first six points, then used a 10-0 run to build a 16-2 lead. It was smooth sailing from there.
"We've actually been able to get off to good starts in all four games," Coach Eric Sanford said. "I credit that to our experience. These seniors are very determined this year."
When the lead eclipsed 35 points late in the third quarter, a running clock was enforced.
"We know that Tates Creek's a very young team, but we don't take anybody for granted," Sanford said. "We take it game by game. Each team's different. So our whole approach is still the same: we still want to come out ready to go, come out hard, pressing like we do and take care of business."
As disappointing as Friday's result was, Tates Creek has at least shown that it knows how to win. The Commodores went 0-30 last season, but last Saturday beat Iroquois 59-39.
"We finally figured that (winning) out," Winn said. "... We know what it feels like, so it is doable. It's just trying to find a way to win and win consistently. The way we played that Saturday we won, we haven't played like that since.
"I can say this, though. My team is a fighting team. No matter what we're down, I tell them don't look at the score, let's just fight; let's play hard. I can say that about them — we have a resolve that we won't quit and won't give up, and that we'll continue to fight. As long as they've got that fight in them, it's going to come out like a lion someday, and I think it's going to happen this year."
HENRY CLAY 74, TATES CREEK 29
HENRY CLAY (4-0) — Richmond 8, Joyce 4, Byars 6, Ke. Davis 16, Green 5, Lutz 1, Coney 7, Jackson 13, Young 10, Long 1, Jones 3. Totals 29-52 14-24 74.
TATES CREEK (1-4) — Bentley 0, Shannon 3, Wilson 4, Hamill 6, D. Woods 0, Martin 4, C. Nsimpasi 3, Brown 5, Brown 4. Totals 10-35 9-15 29.
Henry Clay 20 23 20 11—74
Tates Creek 3 11 10 5—29
Three-point goals — Henry Clay 2-5; Tates Creek 0-3.