Chad Lawrence threw for 184 yards and two scores to lead Simon Kenton, ranked No. 8 in Dave Cantrall's Rating the State, to a 21-18 victory at No. 23 Henry Clay.
The Pioneers scored 21 straight points after Jerry Williams' 20-yard TD run put the Blue Devils ahead 7-0.
An A.J. Jewell field goal cut Simon Kenton's lead to 21-10, and another TD run by Williams and a two-point conversion made it 21-18, but there were only 15 seconds left.
Williams, Henry Clay's quarterback, finished with 47 yards on 11 carries. He threw for 184 yards. Lawrence had 154 yards on 25 carries for the Pioneers.
No. 21 Tates Creek 33, Paul Dunbar 14: Three big plays by Jontez Jones helped the Commodores win on the road.
Jones caught a 45-yard touchdown pass from Dee Christopher in the first quarter, ran for an 80-yard TD in the third and ended the scoring with a 40-yard interception return in the fourth. Jones finished with 117 rushing yards and three catches for 60 yards.
William Gary and Paul Jones each ran for scores for Dunbar. Jones had 87 yards on 17 carries.
Lexington Christian 30, Breathitt Co. 15: Scout McCamy threw for 265 yards and three touchdowns in the Eagles' win at Breathitt County. McCamy's TDs were thrown to Christian Felden (23 yards), Hunter Rowe (35) and Justin King (31).
Shawn Hoke, who ran for 45 yards and a TD, also kicked a 29-yard field goal.
Josh Fletcher helped account for both of Breathitt's scores, the first on a 2-yard run and the other on a 74-yard pass from Richard Trent.
Cincinnati St. Xavier 17, No. 1 Trinity 10: The Shamrocks, tied for the top spot in the rankings with Highlands, lost their first game of the season to Ohio power Cincinnati St. Xavier.
Conor Hundley led the victors with 206 yards rushing and two touchdown runs, one from 91 yards out. Derek Bishop ran for 102 yards and a score for Trinity.
No. 3 St. Xavier 14, No. 11 Male 7: Daylen Hall ran for a 4-yard score with 18 seconds left to give the Tigers a come-from-behind victory, the Courier-Journal reported.
Male got on the board first with a 46-yard TD pass by Lorentez Barbour to Ronjae Morris in the second quarter. St. Xavier tied it up on Brandon Moore's 6-yard TD run in the third.
No. 5 Bell Co. 42, Johnson Central 18: Corey Davenport ran for 181 yards and two touchdowns in the host Bobcats' win. Quarterback Ben Madon added a 14-yard TD run and a 20-yard TD pass.
No. 16 Covington Catholic 24, Beechwood 21: The Colonels needed a 17-point rally and a 30-yard, fourth-quarter field goal by Evan Talkers to get a win at Beechwood. Gabe Gray's 177 rushing yards included an 80-yard score. Cameron Vocke added a 9-yard TD run and a 51-yard catch from Michael Colosimo.
Franklin Co. 20, Frankfort 12: Zach Bowman threw two TD passes and ran for another score and Franklin County rallied for a win at Frankfort. Frankfort led 12-6 before Bowman threw a 5-yard TD to Will Bell and later ran for a 2-yard TD. Bell also caught a 77-yard TD pass in the first quarter.
Scott Co. 40, Oldham Co. 14: Josh Walls' two long scores, a 64-yard rush and a 70-yard catch, ignited the Cardinals' rout of visiting Oldham County. Kevo Edwards added three scoring runs from 4, 4 and 9 yards out. Walls had 104 yards rushing and 129 yards receiving.
West Jessamine 48, Paris 8: The Colts scored three of their seven TDs on defense and special teams, and Matt Carbol ran for two and threw for another in a win at Paris.
Henry Co. 45, Anderson Co. 42: The Wildcats scored the final 18 points, including a game-winning field goal by Dylan Doll with 10 seconds left.
Henry County quarterback Lue Magness had four TD runs to go with two passing scores. That helped the Wildcats overcome five TD runs and 259 yards rushing by Anderson County's Ethan Kelly.
North Hardin 35, Elizabethtown 8: Nayim Johnson scored on 14-yard and 13-yard TD runs in the Trojans' road victory. North Hardin quarterback Vincent Davis added a 1-yard scoring run and a 29-yard TD pass.
Bath Co. 21, Berea 14: Bath County scored twice in the fourth quarter, both on Clark Kissick passes to Jason Little, to rally for a win at home against Berea.