DeShawn Newton threw for 172 yards and three TDs, Jalen Washington rushed for 173 yards and a TD, and Frankfort (4-1) crossed the 40-point mark for the third time in four games while besting Lexington Christian.
The Eagles (3-2) fell down 10-0 early before eventually taking a 21-17 lead on a Nick Whitman TD run with 9:07 to play in the third.
LCA relinquished that lead six minutes later when Frankfort's Malik Frank scored from 4 yards out to put the Panthers (4-1) back up 24-21. The hosts then forced an LCA safety following the kickoff and scored another TD with :30 left in the third, capping a 16-0 run spanning 21/2 minutes.
Sam Arnold had 83 yards on two receptions — both for TDs — for the Eagles.