CINCINNATI — Chris Iannetta's two-run single in the top of the 13th inning made the Los Angeles Angels of Anaheim 3-1 winners over the Cincinnati Reds on Monday, the first season-opening interleague game played in the big leagues.
But it was the second loss of the game for the Reds.
The first came in the third inning when left fielder Ryan Ludwick suffered a dislocated right shoulder as he slid into third base.
All in a game that took 4 hours, 45 minutes and had 30 strikeouts to nine hits.
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"Obviously went a little longer than people probably anticipated for an opening-day game," said Jered Weaver, the first of seven Angels pitchers who combined to strike out 13 and hold the Reds to three hits. "But the bullpen did a hell of a job to save it. And you've gotta tip your hat to (Reds starter Johnny) Cueto. He threw a heck of a game as well. It was nice for us to be able to come out on top."
Cueto pitched seven innings of one-run, seven-hit ball, striking out nine. The run came on Iannetta's 390-foot third-inning home run.
"He started off, made a couple good pitches, then left a changeup up," Iannetta said, "and I was able to get the barrel to it."
The Reds got their run in the bottom of the third, but lost Ludwick on the play.
With Shin-Soo Choo on third and Ludwick on first, a Weaver wild pitch skipped away from catcher Iannetta.
Choo scored on a close play at the plate. Ludwick took second and, when he spied Weaver arguing the call, continued to third.
"I got there," said Ludwick, who is scheduled to undergo an MRI test Tuesday. "The ground was a little wet and, when I slid, at first my hand hit the ground and stopped. Usually when you slide, you slide. My hand bit and it just stopped there, and my shoulder popped out a little bit."
Manager Dusty Baker said he'll know more about Ludwick's prognosis Tuesday.
"Sort of disheartening," Baker said. "You hate to see a guy coming off the field holding his arm like that. We had been doing so good the last couple of years with injuries. It's just a temporary setback."
Weaver worked six innings, retiring the last 10 batters he faced. He gave up two hits and two walks, fanning four.
"They've got some boppers in the middle of their lineup and (Weaver) did a good job of mixing and matching and changing speeds," Angels Manager Mike Scioscia said. "His pitch count was getting away from him a little bit and he reeled back in and got through six innings."
Cueto pitched out of a one-out, bases-loaded jam in the seventh. He struck out Iannetta and J.B. Shuck.
The Reds loaded the bases with one out in the eighth, but Garrett Richards struck out Chris Heisey and Jay Bruce.
In the 13th, J.J. Hoover (0-1) yielded a one-out walk to Josh Hamilton, who moved to second on a groundout.
An intentional walk and a hit batsman loaded the bags for Iannetta, who lined a single past diving third baseman Todd Frazier.
"It was a long day up to that point, and I had some pretty forgettable at-bats going into that one," said Iannetta, who struck out his previous three at-bats. "So I just wanted to get a pitch and stay back, and get the barrel to it. Luckily, I was able to do that."
■ A crowd of 43,168 set a Great American Ball Park regular-season record. ... Former University of Kentucky left-hander Scott Downs pitched a scoreless 10th inning for the Angels.
Angels at Reds
When: 7:10 p.m. TV: FS Ohio