2021 University of Kentucky football schedule
| Date....... | Opponent............... | Location............ | TV................... | Time/Score |
| Sept. 4 | Louisiana Monroe | Lexington, Ky. | SEC | W, 45-10 |
| Sept. 11 | Missouri | Lexington, Ky. | SEC | W, 35-28 |
| Sept. 18 | Chattanooga | Lexington, Ky. | SEC+/ESPN+ | W, 28-23 |
| Sept. 25 | South Carolina | Columbia, S.C. | ESPN2 | W, 16-10 |
| Oct. 2 | Florida | Lexington, Ky. | ESPN | W, 20-13 |
| Oct. 9 | LSU | Lexington, Ky. | SEC | W, 42-21 |
| Oct. 16 | Georgia | Athens, Ga. | CBS | L, 30-13 |
| Oct. 30 | Mississippi State | Starkville, Miss. | SEC | L, 31-17 |
| Nov. 6 | Tennessee | Lexington, Ky. | ESPN2 | L, 45-42 |
| Nov. 13 | Vanderbilt | Nashville, Tenn. | ESPN2 | W, 34-17 |
| Nov. 20 | New Mexico State | Lexington, Ky. | SEC | W, 56-16 |
| Nov. 27 | Louisville | Louisville, Ky. | ESPN2 | W, 52-21 |
| Jan. 1 | Iowa (Citrus Bowl) | Orlando, Fla. | ABC-36 | W, 20-17 |
This story was originally published September 22, 2021 at 12:22 PM.